Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis. Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis. Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis. Tacrolimus ointment protopicr fujisawa is an effective agent in a class of topical immunomodulators it has been shown to be safe and effective in adults and children with atopic dermatitis in short and long term treatments